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You shouldn't use Roxicodone if you have critical bronchial asthma or respiratory difficulties, a bowel blockage, or have narrowing with the belly or intestines.Cytochrome P450 3A4 Interaction. The concomitant utilization of Oxycodone/acetaminophen with all cytochrome P450 3A4 inhibitors may perhaps result in a rise in oxycodone plasma concentratio